Not drinking after Lotilaner (Credelio) in dogs

118 reports to the FDA describe not drinking in dogs given Lotilaner. That is 1.2% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

118Reports

33%Marked serious

32%Recovered

6.8%Died or euthanised

3 daysTypical onset

How soon it started

Same day

30 31%

1–2 days

16 16%

3–7 days

22 23%

1–4 weeks

12 12%

Over a month

17 18%

How the animals did

Recovered

38 32%

Still unwell when reported

50 42%

Died

3 2.5%

Euthanised

5 4.2%

Not known

22 19%

Problems reported at the same time

102 86%

64 54%

46 39%

37 31%

16 14%

15 13%

14 12%

14 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause not drinking in dogs?: 118 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Not drinking with similar medicines

Not drinking after Fluralaner (Bravecto) 487 reports · 0.7% of its reports
Not drinking after Afoxolaner (NexGard) 382 reports · 0.7% of its reports
Not drinking after Sarolaner (Simparica) 113 reports · 0.7% of its reports
Not drinking after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 52 reports · 0.6% of its reports
Not drinking after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 33 reports · 1.1% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with not drinking