Dehydration after Lotilaner (Credelio) in dogs

76 reports to the FDA describe dehydration in dogs given Lotilaner. That is 0.8% of all reports for this medicine, compared with 0.7% across reports for all dog medicines.

76Reports

51%Marked serious

21%Recovered

13%Died or euthanised

6 daysTypical onset

How soon it started

Same day

9 15%

1–2 days

18 29%

3–7 days

12 19%

1–4 weeks

3 4.8%

Over a month

20 32%

How the animals did

Recovered

16 21%

Still unwell when reported

37 49%

Died

4 5.3%

Euthanised

6 7.9%

Not known

13 17%

Problems reported at the same time

49 64%

38 50%

36 47%

26 34%

16 21%

14 18%

14 18%

11 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lotilaner kills fleas and ticks; monthly chewable.

Products with this ingredient include Credelio. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Lotilaner cause dehydration in dogs?: 76 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Dehydration with similar medicines

Dehydration after Fluralaner (Bravecto) 381 reports · 0.6% of its reports
Dehydration after Afoxolaner (NexGard) 272 reports · 0.5% of its reports
Dehydration after Sarolaner (Simparica) 95 reports · 0.6% of its reports
Dehydration after Afoxolaner + Moxidectin + Pyrantel (NexGard PLUS) 47 reports · 0.5% of its reports
Dehydration after Lotilaner + Moxidectin + Praziquantel + Pyrantel (Credelio Quattro) 27 reports · 0.9% of its reports

All reported side effects of Lotilaner in dogs · Medicines most reported with dehydration