Lethargy after Pyriproxyfen in dogs

The FDA has received 46 reports of lethargy in dogs after Pyriproxyfen. That is 15% of all reports for this medicine, compared with 11% across reports for all dog medicines.

46Reports
24%Marked serious
65%Recovered
4.3%Died or euthanised
30 daysTypical onset
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How soon it started

Same day
9 24%
1–2 days
3 8.1%
3–7 days
2 5.4%
1–4 weeks
5 14%
Over a month
18 49%

How the animals did

Recovered
26 57%
Recovered with lasting effects
4 8.7%
Still unwell when reported
4 8.7%
Died
1 2.2%
Euthanised
1 2.2%
Not known
10 22%

Problems reported at the same time

18 39%
Behaviour change
7 15%
Tremors
6 13%
Disorientation
5 11%
Blood problems
4 8.7%
Weight loss
4 8.7%
Diarrhea
3 6.5%

Age of the animals

Under 1 year
10
1–3 years
20
4–7 years
10
8–11 years
4
12+ years
2

About this medicine

Type: medicine.

Questions owners ask

Can Pyriproxyfen cause lethargy in dogs?
46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 30 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lethargy with similar medicines

All reported side effects of Pyriproxyfen in dogs · Medicines most reported with lethargy