Peritonitis after Polysulfated Glycosaminoglycan in dogs

The FDA has received 23 reports of peritonitis in dogs after Polysulfated Glycosaminoglycan. That is 0.4% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports
83%Marked serious
43%Recovered
43%Died or euthanised
62 daysTypical onset
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How soon it started

Same day
0 0.0%
1–2 days
1 6.7%
3–7 days
0 0.0%
1–4 weeks
6 40%
Over a month
8 53%

How the animals did

Recovered
8 35%
Recovered with lasting effects
2 8.7%
Still unwell when reported
2 8.7%
Died
6 26%
Euthanised
4 17%
Not known
1 4.3%

Problems reported at the same time

21 91%
12 52%
Gastric perforation
11 48%
10 43%
Intestinal perforation
8 35%

Age of the animals

Under 1 year
0
1–3 years
3
4–7 years
5
8–11 years
13
12+ years
2

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause peritonitis in dogs?
23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 62 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Peritonitis with similar medicines

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with peritonitis