Frequent urination after Polysulfated Glycosaminoglycan in dogs

The FDA has received 25 reports of frequent urination in dogs after Polysulfated Glycosaminoglycan. That is 0.5% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

25Reports

44%Marked serious

32%Recovered

12%Died or euthanised

17 daysTypical onset

How soon it started

Same day

1 5.9%

1–2 days

2 12%

3–7 days

1 5.9%

1–4 weeks

10 59%

Over a month

3 18%

How the animals did

Recovered

8 32%

Still unwell when reported

6 24%

Died

1 4.0%

Euthanised

2 8.0%

Not known

8 32%

Problems reported at the same time

11 44%

8 32%

6 24%

4 16%

4 16%

3 12%

3 12%

3 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Polysulfated Glycosaminoglycan cause frequent urination in dogs?: 25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 17 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Frequent urination with similar medicines

Frequent urination after Diphenhydramine 24 reports · 0.5% of its reports
Frequent urination after Cefpodoxime 25 reports · 0.6% of its reports
Frequent urination after Famotidine 20 reports · 0.8% of its reports

All reported side effects of Polysulfated Glycosaminoglycan in dogs · Medicines most reported with frequent urination