Injection site reaction after Pentobarbital + Phenytoin in dogs

The FDA has received 35 reports of injection site reaction in dogs after Pentobarbital + Phenytoin. That is 4.1% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

35Reports
31%Marked serious
0.0%Recovered
97%Died or euthanised
–Typical onset
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How the animals did

Died
22 63%
Euthanised
12 34%
Not known
1 2.9%

Problems reported at the same time

9 26%
Behaviour change
3 8.6%
3 8.6%
Paddling
2 5.7%

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
2
8–11 years
6
12+ years
6

About this medicine

Type: medicine.

Questions owners ask

Can Pentobarbital + Phenytoin cause injection site reaction in dogs?
35 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

All reported side effects of Pentobarbital + Phenytoin in dogs · Medicines most reported with injection site reaction