Elevated amylase after Ondansetron in dogs

25 reports to the FDA describe elevated amylase in dogs given Ondansetron. That is 3.8% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

25Reports
92%Marked serious
4.0%Recovered
68%Died or euthanised
32 daysTypical onset
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How soon it started

Same day
3 13%
1–2 days
1 4.2%
3–7 days
1 4.2%
1–4 weeks
7 29%
Over a month
12 50%

How the animals did

Recovered
1 4.0%
Still unwell when reported
5 20%
Died
1 4.0%
Euthanised
16 64%
Not known
2 8.0%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
7
4–7 years
4
8–11 years
12
12+ years
2

About this medicine

Type: medicine.

Questions owners ask

Can Ondansetron cause elevated amylase in dogs?
25 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 32 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated amylase with similar medicines

All reported side effects of Ondansetron in dogs · Medicines most reported with elevated amylase