Monocytosis after Ondansetron in dogs

58 reports to the FDA describe monocytosis in dogs given Ondansetron. That is 8.7% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

58Reports
90%Marked serious
5.2%Recovered
38%Died or euthanised
13 daysTypical onset
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How soon it started

Same day
8 15%
1–2 days
10 19%
3–7 days
7 13%
1–4 weeks
12 23%
Over a month
15 29%

How the animals did

Recovered
3 5.2%
Still unwell when reported
20 34%
Died
7 12%
Euthanised
15 26%
Not known
13 22%

Problems reported at the same time

Age of the animals

Under 1 year
4
1–3 years
15
4–7 years
18
8–11 years
14
12+ years
7

About this medicine

Type: medicine.

Questions owners ask

Can Ondansetron cause monocytosis in dogs?
58 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 13 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Monocytosis with similar medicines

All reported side effects of Ondansetron in dogs · Medicines most reported with monocytosis