Unresponsive after Oclacitinib (Apoquel) in dogs

The FDA has received 268 reports of unresponsive in dogs after Oclacitinib. That is 0.9% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

268Reports

93%Marked serious

11%Recovered

24%Died or euthanised

56 daysTypical onset

How soon it started

Same day

22 13%

1–2 days

9 5.5%

3–7 days

10 6.1%

1–4 weeks

23 14%

Over a month

99 61%

How the animals did

Recovered

28 10%

Recovered with lasting effects

1 0.4%

Still unwell when reported

146 54%

Died

28 10%

Euthanised

36 13%

Not known

29 11%

Problems reported at the same time

62 23%

32 12%

32 12%

31 12%

23 8.6%

22 8.2%

19 7.1%

19 7.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

122

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause unresponsive in dogs?: 268 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 56 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unresponsive with similar medicines

Unresponsive after Cyclosporine (Atopica) 90 reports · 0.6% of its reports

All reported side effects of Oclacitinib in dogs · Medicines most reported with unresponsive