Swollen limb after Oclacitinib (Apoquel) in dogs

The FDA has received 56 reports of swollen limb in dogs after Oclacitinib. That is 0.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

56Reports

52%Marked serious

3.6%Recovered

13%Died or euthanised

22 daysTypical onset

How soon it started

Same day

6 14%

1–2 days

4 9.3%

3–7 days

4 9.3%

1–4 weeks

13 30%

Over a month

16 37%

How the animals did

Recovered

2 3.6%

Still unwell when reported

38 68%

Died

6 11%

Euthanised

1 1.8%

Not known

9 16%

Problems reported at the same time

Swelling

19 34%

Lameness

19 34%

Loss of appetite

12 21%

Didn't work as expected

12 21%

Injection site reaction

10 18%

Lethargy

9 16%

Wound

9 16%

Death

7 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause swollen limb in dogs?: 56 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 22 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Oclacitinib in dogs · Medicines most reported with swollen limb