Elevated globulins after Oclacitinib (Apoquel) in dogs

162 reports to the FDA describe elevated globulins in dogs given Oclacitinib. That is 0.6% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

162Reports
49%Marked serious
2.5%Recovered
14%Died or euthanised
48 daysTypical onset
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How soon it started

Same day
17 15%
1–2 days
5 4.5%
3–7 days
11 9.9%
1–4 weeks
13 12%
Over a month
65 59%

How the animals did

Recovered
4 2.5%
Still unwell when reported
113 70%
Died
5 3.1%
Euthanised
17 10%
Not known
23 14%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
22
4–7 years
50
8–11 years
62
12+ years
27

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause elevated globulins in dogs?
162 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 48 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated globulins with similar medicines

All reported side effects of Oclacitinib in dogs · Medicines most reported with elevated globulins