Application site reaction after Oclacitinib (Apoquel) in dogs

The FDA has received 73 reports of application site reaction in dogs after Oclacitinib. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

73Reports

25%Marked serious

29%Recovered

1.4%Died or euthanised

14 daysTypical onset

How soon it started

Same day

11 19%

1–2 days

3 5.3%

3–7 days

9 16%

1–4 weeks

13 23%

Over a month

21 37%

How the animals did

Recovered

20 27%

Recovered with lasting effects

1 1.4%

Still unwell when reported

28 38%

Died

1 1.4%

Not known

23 32%

Problems reported at the same time

20 27%

20 27%

12 16%

12 16%

Skin rash or irritation

9 12%

Didn't work as expected

8 11%

Abnormal cytology

8 11%

Loss of appetite

7 9.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Oclacitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Apoquel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Oclacitinib cause application site reaction in dogs?: 73 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Oclacitinib in dogs · Medicines most reported with application site reaction