Reluctant to move after Moxidectin (ProHeart 6) in dogs

290 reports to the FDA describe reluctant to move in dogs given Moxidectin. That is 0.6% of all reports for this medicine, compared with 0.5% across reports for all dog medicines.

290Reports

30%Marked serious

15%Recovered

18%Died or euthanised

Same dayTypical onset

How soon it started

Same day

81 57%

1–2 days

29 20%

3–7 days

18 13%

1–4 weeks

9 6.3%

Over a month

6 4.2%

How the animals did

Recovered

42 14%

Recovered with lasting effects

1 0.3%

Still unwell when reported

81 28%

Died

45 16%

Euthanised

6 2.1%

Not known

115 40%

Problems reported at the same time

153 53%

98 34%

67 23%

50 17%

44 15%

44 15%

43 15%

43 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

103

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause reluctant to move in dogs?: 290 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Reluctant to move with similar medicines

Reluctant to move after Ivermectin + Pyrantel (Heartgard Plus) 256 reports · 0.2% of its reports
Reluctant to move after Milbemycin Oxime + Spinosad (Trifexis) 394 reports · 0.3% of its reports
Reluctant to move after Milbemycin Oxime + Praziquantel (Interceptor Plus) 84 reports · 0.3% of its reports
Reluctant to move after Milbemycin Oxime (Interceptor) 64 reports · 0.2% of its reports
Reluctant to move after Selamectin (Revolution) 86 reports · 0.3% of its reports
Reluctant to move after Ivermectin (Heartgard) 56 reports · 0.5% of its reports
Reluctant to move after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 26 reports · 0.3% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with reluctant to move