Reluctant to move after Milbemycin Oxime + Spinosad (Trifexis) in dogs

394 reports to the FDA describe reluctant to move in dogs given Milbemycin Oxime + Spinosad. That is 0.3% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported less often than average with this medicine.

394Reports

40%Marked serious

52%Recovered

8.4%Died or euthanised

1 daysTypical onset

How soon it started

Same day

134 48%

1–2 days

42 15%

3–7 days

6 2.1%

1–4 weeks

22 7.8%

Over a month

77 27%

How the animals did

Recovered

168 43%

Recovered with lasting effects

36 9.1%

Still unwell when reported

57 14%

Died

21 5.3%

Euthanised

12 3.0%

Not known

100 25%

Problems reported at the same time

217 55%

149 38%

114 29%

108 27%

76 19%

52 13%

46 12%

39 9.9%

Age of the animals

Under 1 year

1–3 years

149

4–7 years

103

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Spinosad kills fleas; monthly chewable.

Products with this combination include Trifexis. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Spinosad cause reluctant to move in dogs?: 394 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Reluctant to move with similar medicines

Reluctant to move after Ivermectin + Pyrantel (Heartgard Plus) 256 reports · 0.2% of its reports
Reluctant to move after Moxidectin (ProHeart 6) 290 reports · 0.6% of its reports
Reluctant to move after Milbemycin Oxime + Praziquantel (Interceptor Plus) 84 reports · 0.3% of its reports
Reluctant to move after Milbemycin Oxime (Interceptor) 64 reports · 0.2% of its reports
Reluctant to move after Selamectin (Revolution) 86 reports · 0.3% of its reports
Reluctant to move after Ivermectin (Heartgard) 56 reports · 0.5% of its reports
Reluctant to move after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 26 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime + Spinosad in dogs · Medicines most reported with reluctant to move