Nausea after Moxidectin (ProHeart 6) in dogs

146 reports to the FDA describe nausea in dogs given Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

146Reports

59%Marked serious

34%Recovered

6.2%Died or euthanised

Same dayTypical onset

How soon it started

Same day

87 70%

1–2 days

17 14%

3–7 days

6 4.8%

1–4 weeks

2 1.6%

Over a month

12 9.7%

How the animals did

Recovered

49 34%

Recovered with lasting effects

1 0.7%

Still unwell when reported

75 51%

Died

6 4.1%

Euthanised

3 2.1%

Not known

12 8.2%

Problems reported at the same time

82 56%

63 43%

42 29%

32 22%

32 22%

28 19%

25 17%

20 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause nausea in dogs?: 146 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Nausea with similar medicines

Nausea after Ivermectin + Pyrantel (Heartgard Plus) 233 reports · 0.2% of its reports
Nausea after Milbemycin Oxime + Spinosad (Trifexis) 876 reports · 0.7% of its reports
Nausea after Milbemycin Oxime + Praziquantel (Interceptor Plus) 126 reports · 0.4% of its reports
Nausea after Milbemycin Oxime (Interceptor) 65 reports · 0.2% of its reports
Nausea after Selamectin (Revolution) 56 reports · 0.2% of its reports
Nausea after Ivermectin (Heartgard) 55 reports · 0.5% of its reports
Nausea after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 26 reports · 0.3% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with nausea