Nausea after Milbemycin Oxime (Interceptor) in dogs

65 reports to the FDA describe nausea in dogs given Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

65Reports

23%Marked serious

29%Recovered

6.2%Died or euthanised

3 daysTypical onset

How soon it started

Same day

12 43%

1–2 days

2 7.1%

3–7 days

2 7.1%

1–4 weeks

1 3.6%

Over a month

11 39%

How the animals did

Recovered

19 29%

Still unwell when reported

15 23%

Died

1 1.5%

Euthanised

3 4.6%

Not known

27 42%

Problems reported at the same time

32 49%

30 46%

24 37%

11 17%

9 14%

8 12%

7 11%

Didn't work as expected

6 9.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause nausea in dogs?: 65 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Nausea with similar medicines

Nausea after Ivermectin + Pyrantel (Heartgard Plus) 233 reports · 0.2% of its reports
Nausea after Milbemycin Oxime + Spinosad (Trifexis) 876 reports · 0.7% of its reports
Nausea after Moxidectin (ProHeart 6) 146 reports · 0.3% of its reports
Nausea after Milbemycin Oxime + Praziquantel (Interceptor Plus) 126 reports · 0.4% of its reports
Nausea after Selamectin (Revolution) 56 reports · 0.2% of its reports
Nausea after Ivermectin (Heartgard) 55 reports · 0.5% of its reports
Nausea after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 26 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with nausea