Blood in vomit after Moxidectin (ProHeart 6) in dogs

The FDA has received 314 reports of blood in vomit in dogs after Moxidectin. That is 0.6% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

314Reports

54%Marked serious

21%Recovered

18%Died or euthanised

Same dayTypical onset

How soon it started

Same day

150 69%

1–2 days

35 16%

3–7 days

12 5.5%

1–4 weeks

14 6.4%

Over a month

7 3.2%

How the animals did

Recovered

65 21%

Still unwell when reported

131 42%

Died

45 14%

Euthanised

10 3.2%

Not known

63 20%

Problems reported at the same time

150 48%

141 45%

111 35%

103 33%

75 24%

56 18%

52 17%

49 16%

Age of the animals

Under 1 year

1–3 years

138

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause blood in vomit in dogs?: 314 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood in vomit with similar medicines

Blood in vomit after Ivermectin + Pyrantel (Heartgard Plus) 183 reports · 0.1% of its reports
Blood in vomit after Milbemycin Oxime + Spinosad (Trifexis) 144 reports · 0.1% of its reports
Blood in vomit after Milbemycin Oxime + Praziquantel (Interceptor Plus) 71 reports · 0.2% of its reports
Blood in vomit after Milbemycin Oxime (Interceptor) 52 reports · 0.2% of its reports
Blood in vomit after Selamectin (Revolution) 72 reports · 0.2% of its reports
Blood in vomit after Ivermectin (Heartgard) 34 reports · 0.3% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with blood in vomit