Blood in vomit after Ivermectin + Pyrantel (Heartgard Plus) in dogs

183 reports to the FDA describe blood in vomit in dogs given Ivermectin + Pyrantel. That is 0.1% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

183Reports

49%Marked serious

25%Recovered

11%Died or euthanised

5 daysTypical onset

How soon it started

Same day

20 21%

1–2 days

20 21%

3–7 days

12 13%

1–4 weeks

16 17%

Over a month

28 29%

How the animals did

Recovered

44 24%

Recovered with lasting effects

2 1.1%

Still unwell when reported

34 19%

Died

14 7.7%

Euthanised

7 3.8%

Not known

82 45%

Problems reported at the same time

75 41%

62 34%

50 27%

45 25%

21 11%

18 9.8%

17 9.3%

15 8.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Pyrantel treats roundworms and hookworms.

Products with this combination include Heartgard Plus, Tri-Heart Plus, Iverhart Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Pyrantel cause blood in vomit in dogs?: 183 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood in vomit with similar medicines

Blood in vomit after Milbemycin Oxime + Spinosad (Trifexis) 144 reports · 0.1% of its reports
Blood in vomit after Moxidectin (ProHeart 6) 314 reports · 0.6% of its reports
Blood in vomit after Milbemycin Oxime + Praziquantel (Interceptor Plus) 71 reports · 0.2% of its reports
Blood in vomit after Milbemycin Oxime (Interceptor) 52 reports · 0.2% of its reports
Blood in vomit after Selamectin (Revolution) 72 reports · 0.2% of its reports
Blood in vomit after Ivermectin (Heartgard) 34 reports · 0.3% of its reports

All reported side effects of Ivermectin + Pyrantel in dogs · Medicines most reported with blood in vomit