Blood in vomit after Milbemycin Oxime (Interceptor) in dogs

52 reports to the FDA describe blood in vomit in dogs given Milbemycin Oxime. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

52Reports

15%Marked serious

13%Recovered

19%Died or euthanised

92 daysTypical onset

How soon it started

Same day

3 25%

1–2 days

0 0.0%

3–7 days

1 8.3%

1–4 weeks

0 0.0%

Over a month

8 67%

How the animals did

Recovered

7 13%

Still unwell when reported

2 3.8%

Died

9 17%

Euthanised

1 1.9%

Not known

33 63%

Problems reported at the same time

24 46%

23 44%

22 42%

12 23%

11 21%

7 13%

6 12%

6 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause blood in vomit in dogs?: 52 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 92 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood in vomit with similar medicines

Blood in vomit after Ivermectin + Pyrantel (Heartgard Plus) 183 reports · 0.1% of its reports
Blood in vomit after Milbemycin Oxime + Spinosad (Trifexis) 144 reports · 0.1% of its reports
Blood in vomit after Moxidectin (ProHeart 6) 314 reports · 0.6% of its reports
Blood in vomit after Milbemycin Oxime + Praziquantel (Interceptor Plus) 71 reports · 0.2% of its reports
Blood in vomit after Selamectin (Revolution) 72 reports · 0.2% of its reports
Blood in vomit after Ivermectin (Heartgard) 34 reports · 0.3% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with blood in vomit