Blood in vomit after Ivermectin (Heartgard) in dogs

34 reports to the FDA describe blood in vomit in dogs given Ivermectin. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

34Reports
35%Marked serious
21%Recovered
15%Died or euthanised
40 daysTypical onset
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How soon it started

Same day
1 7.1%
1–2 days
3 21%
3–7 days
1 7.1%
1–4 weeks
2 14%
Over a month
7 50%

How the animals did

Recovered
7 21%
Still unwell when reported
12 35%
Died
5 15%
Not known
10 29%

Problems reported at the same time

Vomiting
19 56%
Diarrhea
14 41%
Loss of appetite
10 29%
Lethargy
9 26%
Death
5 15%
Blood problems
5 15%
Liver problems
5 15%
Nausea
4 12%

Age of the animals

Under 1 year
3
1–3 years
9
4–7 years
8
8–11 years
5
12+ years
8

About this medicine

Ivermectin prevents heartworm disease (monthly).

Products with this ingredient include Heartgard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin cause blood in vomit in dogs?
34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 40 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood in vomit with similar medicines

All reported side effects of Ivermectin in dogs · Medicines most reported with blood in vomit