Urinary incontinence after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

The FDA has received 112 reports of urinary incontinence in dogs after Milbemycin Oxime + Praziquantel. That is 0.4% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

112Reports

28%Marked serious

24%Recovered

6.3%Died or euthanised

14 daysTypical onset

How soon it started

Same day

13 20%

1–2 days

11 17%

3–7 days

7 11%

1–4 weeks

7 11%

Over a month

28 42%

How the animals did

Recovered

23 21%

Recovered with lasting effects

4 3.6%

Still unwell when reported

35 31%

Died

2 1.8%

Euthanised

5 4.5%

Not known

43 38%

Problems reported at the same time

Vomiting

26 23%

Lethargy

20 18%

Didn't prevent heartworm

15 13%

13 12%

12 11%

12 11%

12 11%

11 9.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause urinary incontinence in dogs?: 112 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

Urinary incontinence after Ivermectin + Pyrantel (Heartgard Plus) 190 reports · 0.1% of its reports
Urinary incontinence after Milbemycin Oxime + Spinosad (Trifexis) 309 reports · 0.2% of its reports
Urinary incontinence after Moxidectin (ProHeart 6) 171 reports · 0.3% of its reports
Urinary incontinence after Milbemycin Oxime (Interceptor) 86 reports · 0.3% of its reports
Urinary incontinence after Selamectin (Revolution) 86 reports · 0.3% of its reports
Urinary incontinence after Ivermectin (Heartgard) 46 reports · 0.4% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with urinary incontinence