Urinary incontinence after Moxidectin (ProHeart 6) in dogs

171 reports to the FDA describe urinary incontinence in dogs given Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

171Reports

53%Marked serious

13%Recovered

22%Died or euthanised

Same dayTypical onset

How soon it started

Same day

62 51%

1–2 days

17 14%

3–7 days

7 5.8%

1–4 weeks

8 6.6%

Over a month

27 22%

How the animals did

Recovered

22 13%

Still unwell when reported

75 44%

Died

25 15%

Euthanised

12 7.0%

Not known

37 22%

Problems reported at the same time

55 32%

50 29%

41 24%

37 22%

36 21%

31 18%

29 17%

27 16%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause urinary incontinence in dogs?: 171 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Urinary incontinence with similar medicines

Urinary incontinence after Ivermectin + Pyrantel (Heartgard Plus) 190 reports · 0.1% of its reports
Urinary incontinence after Milbemycin Oxime + Spinosad (Trifexis) 309 reports · 0.2% of its reports
Urinary incontinence after Milbemycin Oxime + Praziquantel (Interceptor Plus) 112 reports · 0.4% of its reports
Urinary incontinence after Milbemycin Oxime (Interceptor) 86 reports · 0.3% of its reports
Urinary incontinence after Selamectin (Revolution) 86 reports · 0.3% of its reports
Urinary incontinence after Ivermectin (Heartgard) 46 reports · 0.4% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with urinary incontinence