Unpalatable after Milbemycin Oxime + Praziquantel (Interceptor Plus) in dogs

183 reports to the FDA describe unpalatable in dogs given Milbemycin Oxime + Praziquantel. That is 0.6% of all reports for this medicine, compared with 0.6% across reports for all dog medicines.

183Reports

11%Marked serious

44%Recovered

4.4%Died or euthanised

Same dayTypical onset

How soon it started

Same day

82 58%

1–2 days

8 5.6%

3–7 days

2 1.4%

1–4 weeks

5 3.5%

Over a month

45 32%

How the animals did

Recovered

81 44%

Still unwell when reported

26 14%

Died

6 3.3%

Euthanised

2 1.1%

Not known

68 37%

Problems reported at the same time

72 39%

30 16%

30 16%

26 14%

Didn't prevent heartworm

18 9.8%

Loss of appetite

16 8.7%

Didn't stop worms

15 8.2%

Product defect, product difficult to use/handle

13 7.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Interceptor Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime + Praziquantel cause unpalatable in dogs?: 183 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Unpalatable with similar medicines

Unpalatable after Ivermectin + Pyrantel (Heartgard Plus) 647 reports · 0.4% of its reports
Unpalatable after Milbemycin Oxime + Spinosad (Trifexis) 2,574 reports · 2.0% of its reports
Unpalatable after Milbemycin Oxime (Interceptor) 45 reports · 0.2% of its reports
Unpalatable after Ivermectin (Heartgard) 84 reports · 0.7% of its reports

All reported side effects of Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with unpalatable