Injection site reaction after Methadone in dogs

21 reports to the FDA describe injection site reaction in dogs given Methadone. That is 8.8% of all reports for this medicine, compared with 1.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

21Reports

57%Marked serious

4.8%Recovered

0.0%Died or euthanised

2 daysTypical onset

How soon it started

Same day

6 29%

1–2 days

6 29%

3–7 days

5 24%

1–4 weeks

4 19%

Over a month

0 0.0%

How the animals did

Recovered

1 4.8%

Still unwell when reported

7 33%

Not known

13 62%

Problems reported at the same time

Swelling

12 57%

Didn't work as expected

9 43%

Lethargy

8 38%

Pain

6 29%

Diarrhea

5 24%

Swollen limb

5 24%

Breathing problems

4 19%

Lameness

4 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Methadone cause injection site reaction in dogs?: 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Injection site reaction with similar medicines

Injection site reaction after Melarsomine (Immiticide) 3,290 reports · 15% of its reports
Injection site reaction after Polysulfated Glycosaminoglycan 263 reports · 4.8% of its reports
Injection site reaction after Diphenhydramine 398 reports · 8.4% of its reports
Injection site reaction after Butorphanol 479 reports · 11% of its reports
Injection site reaction after Cefpodoxime 81 reports · 2.0% of its reports
Injection site reaction after Tramadol 123 reports · 3.3% of its reports
Injection site reaction after Desoxycorticosterone Pivalate 165 reports · 4.9% of its reports
Injection site reaction after Propofol 170 reports · 5.5% of its reports
Injection site reaction after Isoflurane 126 reports · 4.6% of its reports
Injection site reaction after Cephalexin 31 reports · 1.2% of its reports

All reported side effects of Methadone in dogs · Medicines most reported with injection site reaction