Didn't work as expected after Methadone in dogs

The FDA has received 46 reports of didn't work as expected in dogs after Methadone. That is 19% of all reports for this medicine, compared with 13% across reports for all dog medicines, so it is reported unusually often with this medicine.

46Reports

74%Marked serious

48%Recovered

11%Died or euthanised

Same dayTypical onset

How soon it started

Same day

23 56%

1–2 days

10 24%

3–7 days

3 7.3%

1–4 weeks

1 2.4%

Over a month

4 9.8%

How the animals did

Recovered

22 48%

Still unwell when reported

8 17%

Died

2 4.3%

Euthanised

3 6.5%

Not known

11 24%

Problems reported at the same time

Loss of appetite

10 22%

Pain

9 20%

Injection site reaction

9 20%

8 17%

7 15%

7 15%

5 11%

Skin redness

5 11%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Methadone cause didn't work as expected in dogs?: 46 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't work as expected with similar medicines

Didn't work as expected after Melarsomine (Immiticide) 646 reports · 2.8% of its reports
Didn't work as expected after Polysulfated Glycosaminoglycan 698 reports · 13% of its reports
Didn't work as expected after Diphenhydramine 585 reports · 12% of its reports
Didn't work as expected after Butorphanol 1,022 reports · 23% of its reports
Didn't work as expected after Cefpodoxime 671 reports · 17% of its reports
Didn't work as expected after Tramadol 475 reports · 13% of its reports
Didn't work as expected after Florfenicol + Mometasone + Terbinafine 969 reports · 27% of its reports
Didn't work as expected after Desoxycorticosterone Pivalate 355 reports · 11% of its reports
Didn't work as expected after Propofol 600 reports · 20% of its reports
Didn't work as expected after Dirlotapide 712 reports · 25% of its reports

All reported side effects of Methadone in dogs · Medicines most reported with didn't work as expected