Excessive thirst after Lufenuron + Milbemycin Oxime (Sentinel) in dogs

The FDA has received 131 reports of excessive thirst in dogs after Lufenuron + Milbemycin Oxime. That is 0.5% of all reports for this medicine, compared with 1.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

131Reports

36%Marked serious

21%Recovered

12%Died or euthanised

6 daysTypical onset

How soon it started

Same day

11 26%

1–2 days

7 17%

3–7 days

5 12%

1–4 weeks

5 12%

Over a month

14 33%

How the animals did

Recovered

27 21%

Recovered with lasting effects

1 0.8%

Still unwell when reported

21 16%

Died

12 9.2%

Euthanised

4 3.1%

Not known

66 50%

Problems reported at the same time

56 43%

53 40%

45 34%

41 31%

27 21%

19 15%

Decreased urine concentration

19 15%

Weight loss

17 13%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this combination include Sentinel. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime cause excessive thirst in dogs?: 131 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 6 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive thirst with similar medicines

Excessive thirst after Spinosad (Comfortis) 374 reports · 0.7% of its reports
Excessive thirst after Imidacloprid + Moxidectin (Advantage Multi) 114 reports · 0.9% of its reports
Excessive thirst after Nitenpyram (Capstar) 50 reports · 0.5% of its reports
Excessive thirst after Fipronil + S-methoprene (Frontline Plus) 23 reports · 0.8% of its reports
Excessive thirst after Flumethrin + Imidacloprid (Seresto) 21 reports · 0.9% of its reports
Excessive thirst after Fipronil 23 reports · 1.6% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime in dogs · Medicines most reported with excessive thirst