Restlessness or agitation after Lokivetmab (Cytopoint) in dogs

The FDA has received 144 reports of restlessness or agitation in dogs after Lokivetmab. That is 2.2% of all reports for this medicine, compared with 1.6% across reports for all dog medicines.

144Reports

47%Marked serious

23%Recovered

12%Died or euthanised

4 daysTypical onset

How soon it started

Same day

39 33%

1–2 days

16 14%

3–7 days

10 8.5%

1–4 weeks

18 15%

Over a month

34 29%

How the animals did

Recovered

32 22%

Recovered with lasting effects

1 0.7%

Still unwell when reported

66 46%

Died

8 5.6%

Euthanised

9 6.3%

Not known

28 19%

Problems reported at the same time

46 32%

41 28%

31 22%

30 21%

26 18%

25 17%

25 17%

24 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause restlessness or agitation in dogs?: 144 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 4 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Bedinvetmab (Librela) 416 reports · 2.1% of its reports

All reported side effects of Lokivetmab in dogs · Medicines most reported with restlessness or agitation