Malaise after Lokivetmab (Cytopoint) in dogs

The FDA has received 49 reports of malaise in dogs after Lokivetmab. That is 0.8% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

49Reports

59%Marked serious

4.1%Recovered

12%Died or euthanised

14 daysTypical onset

How soon it started

Same day

7 20%

1–2 days

3 8.6%

3–7 days

4 11%

1–4 weeks

5 14%

Over a month

16 46%

How the animals did

Recovered

1 2.0%

Recovered with lasting effects

1 2.0%

Still unwell when reported

35 71%

Died

5 10%

Euthanised

1 2.0%

Not known

6 12%

Problems reported at the same time

Lethargy

25 51%

Loss of appetite

22 45%

Vomiting

15 31%

Didn't work as expected

11 22%

11 22%

10 20%

8 16%

7 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause malaise in dogs?: 49 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 14 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Malaise with similar medicines

Malaise after Bedinvetmab (Librela) 70 reports · 0.4% of its reports

All reported side effects of Lokivetmab in dogs · Medicines most reported with malaise