Anxiety after Lokivetmab (Cytopoint) in dogs

The FDA has received 79 reports of anxiety in dogs after Lokivetmab. That is 1.2% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

79Reports

56%Marked serious

19%Recovered

11%Died or euthanised

1 daysTypical onset

How soon it started

Same day

29 45%

1–2 days

11 17%

3–7 days

2 3.1%

1–4 weeks

10 15%

Over a month

13 20%

How the animals did

Recovered

15 19%

Still unwell when reported

44 56%

Died

3 3.8%

Euthanised

6 7.6%

Not known

11 14%

Problems reported at the same time

Breathing problems

29 37%

Behaviour change

23 29%

Vomiting

23 29%

Didn't work as expected

20 25%

Lethargy

15 19%

Restlessness or agitation

12 15%

Itching

12 15%

Allergic reaction

12 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lokivetmab controls allergic itch for 4–8 weeks per injection.

Products with this ingredient include Cytopoint. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lokivetmab cause anxiety in dogs?: 79 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Anxiety with similar medicines

Anxiety after Bedinvetmab (Librela) 329 reports · 1.7% of its reports

All reported side effects of Lokivetmab in dogs · Medicines most reported with anxiety