Nystagmus after Leptospirosis Vaccine in dogs

The FDA has received 48 reports of nystagmus in dogs after Leptospirosis Vaccine. That is 0.6% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

48Reports

75%Marked serious

13%Recovered

35%Died or euthanised

1 daysTypical onset

How soon it started

Same day

14 33%

1–2 days

12 29%

3–7 days

8 19%

1–4 weeks

5 12%

Over a month

3 7.1%

How the animals did

Recovered

6 13%

Still unwell when reported

20 42%

Died

5 10%

Euthanised

12 25%

Not known

5 10%

Problems reported at the same time

22 46%

17 35%

15 31%

14 29%

14 29%

Head tilt - neurological disorder

13 27%

Seizures

10 21%

Vestibular disorder

10 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: vaccine.

Mild, short-lived lethargy, soreness or a small lump at the injection site are the most commonly reported vaccine reactions.

Questions owners ask

Can Leptospirosis Vaccine cause nystagmus in dogs?: 48 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 1 day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Nystagmus with similar medicines

Nystagmus after Rabies Vaccine 60 reports · 0.6% of its reports
Nystagmus after Bordetella Vaccine 59 reports · 0.6% of its reports
Nystagmus after Distemper-parvo Vaccine 32 reports · 0.5% of its reports

All reported side effects of Leptospirosis Vaccine in dogs · Medicines most reported with nystagmus