Restlessness or agitation after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs
82 reports to the FDA describe restlessness or agitation in dogs given Ivermectin + Praziquantel + Pyrantel. That is 1.0% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported less often than average with this medicine.
How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.
Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Ivermectin + Praziquantel + Pyrantel cause restlessness or agitation in dogs?
- 82 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within the same day of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Restlessness or agitation with similar medicines
- Restlessness or agitation after Ivermectin + Pyrantel (Heartgard Plus) 1,021 reports · 0.7% of its reports
- Restlessness or agitation after Milbemycin Oxime + Spinosad (Trifexis) 1,101 reports · 0.8% of its reports
- Restlessness or agitation after Moxidectin (ProHeart 6) 508 reports · 1.0% of its reports
- Restlessness or agitation after Milbemycin Oxime + Praziquantel (Interceptor Plus) 222 reports · 0.7% of its reports
- Restlessness or agitation after Milbemycin Oxime (Interceptor) 250 reports · 0.8% of its reports
- Restlessness or agitation after Selamectin (Revolution) 561 reports · 1.9% of its reports
- Restlessness or agitation after Ivermectin (Heartgard) 213 reports · 1.8% of its reports
- Restlessness or agitation after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 20 reports · 1.7% of its reports
All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with restlessness or agitation