Restlessness or agitation after Moxidectin (ProHeart 6) in dogs

508 reports to the FDA describe restlessness or agitation in dogs given Moxidectin. That is 1.0% of all reports for this medicine, compared with 1.6% across reports for all dog medicines, so it is reported less often than average with this medicine.

508Reports

36%Marked serious

28%Recovered

6.3%Died or euthanised

Same dayTypical onset

How soon it started

Same day

248 71%

1–2 days

41 12%

3–7 days

20 5.8%

1–4 weeks

19 5.5%

Over a month

19 5.5%

How the animals did

Recovered

140 28%

Recovered with lasting effects

3 0.6%

Still unwell when reported

178 35%

Died

22 4.3%

Euthanised

10 2.0%

Not known

155 31%

Problems reported at the same time

193 38%

177 35%

128 25%

123 24%

122 24%

101 20%

70 14%

65 13%

Age of the animals

Under 1 year

1–3 years

204

4–7 years

153

8–11 years

12+ years

About this medicine

Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this ingredient include ProHeart 6, ProHeart 12. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Moxidectin cause restlessness or agitation in dogs?: 508 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Restlessness or agitation with similar medicines

Restlessness or agitation after Ivermectin + Pyrantel (Heartgard Plus) 1,021 reports · 0.7% of its reports
Restlessness or agitation after Milbemycin Oxime + Spinosad (Trifexis) 1,101 reports · 0.8% of its reports
Restlessness or agitation after Milbemycin Oxime + Praziquantel (Interceptor Plus) 222 reports · 0.7% of its reports
Restlessness or agitation after Milbemycin Oxime (Interceptor) 250 reports · 0.8% of its reports
Restlessness or agitation after Selamectin (Revolution) 561 reports · 1.9% of its reports
Restlessness or agitation after Ivermectin (Heartgard) 213 reports · 1.8% of its reports
Restlessness or agitation after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) 82 reports · 1.0% of its reports
Restlessness or agitation after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 20 reports · 1.7% of its reports

All reported side effects of Moxidectin in dogs · Medicines most reported with restlessness or agitation