Itching after Ivermectin + Praziquantel + Pyrantel (Iverhart Max) in dogs

93 reports to the FDA describe itching in dogs given Ivermectin + Praziquantel + Pyrantel. That is 1.1% of all reports for this medicine, compared with 4.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

93Reports

37%Marked serious

39%Recovered

1.1%Died or euthanised

Same dayTypical onset

How soon it started

Same day

39 58%

1–2 days

7 10%

3–7 days

5 7.5%

1–4 weeks

9 13%

Over a month

7 10%

How the animals did

Recovered

32 34%

Recovered with lasting effects

4 4.3%

Still unwell when reported

13 14%

Died

1 1.1%

Not known

43 46%

Problems reported at the same time

Vomiting

15 16%

Restlessness or agitation

13 14%

Didn't stop fleas

13 14%

Allergic reaction

10 11%

Skin rash or irritation

9 9.7%

Hair loss

8 8.6%

Lethargy

7 7.5%

Reddening of the skin

7 7.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ivermectin prevents heartworm disease (monthly). Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Iverhart Max. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Ivermectin + Praziquantel + Pyrantel cause itching in dogs?: 93 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Itching with similar medicines

Itching after Ivermectin + Pyrantel (Heartgard Plus) 2,733 reports · 1.9% of its reports
Itching after Milbemycin Oxime + Spinosad (Trifexis) 6,069 reports · 4.7% of its reports
Itching after Moxidectin (ProHeart 6) 2,435 reports · 4.8% of its reports
Itching after Milbemycin Oxime + Praziquantel (Interceptor Plus) 763 reports · 2.4% of its reports
Itching after Milbemycin Oxime (Interceptor) 563 reports · 1.9% of its reports
Itching after Selamectin (Revolution) 2,024 reports · 6.9% of its reports
Itching after Ivermectin (Heartgard) 528 reports · 4.4% of its reports
Itching after Moxidectin + Pyrantel + Sarolaner (Simparica Trio) 57 reports · 4.9% of its reports

All reported side effects of Ivermectin + Praziquantel + Pyrantel in dogs · Medicines most reported with itching