Vomiting after Imidacloprid + Pyriproxyfen in dogs

The FDA has received 30 reports of vomiting in dogs after Imidacloprid + Pyriproxyfen. That is 11% of all reports for this medicine, compared with 28% across reports for all dog medicines, so it is reported less often than average with this medicine.

30Reports

33%Marked serious

43%Recovered

3.3%Died or euthanised

27 daysTypical onset

How soon it started

Same day

4 20%

1–2 days

4 20%

3–7 days

1 5.0%

1–4 weeks

5 25%

Over a month

6 30%

How the animals did

Recovered

13 43%

Still unwell when reported

6 20%

Euthanised

1 3.3%

Not known

10 33%

Problems reported at the same time

Lethargy

12 40%

Diarrhea

8 27%

Loss of appetite

6 20%

Itching

4 13%

Behaviour change

3 10%

Overdose

3 10%

Seizures

2 6.7%

Vocalising

2 6.7%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar).

Questions owners ask

Can Imidacloprid + Pyriproxyfen cause vomiting in dogs?: 30 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 27 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vomiting with similar medicines

Vomiting after Spinosad (Comfortis) 30,909 reports · 54% of its reports
Vomiting after Lufenuron + Milbemycin Oxime (Sentinel) 4,725 reports · 18% of its reports
Vomiting after Imidacloprid + Moxidectin (Advantage Multi) 1,904 reports · 15% of its reports
Vomiting after Nitenpyram (Capstar) 1,204 reports · 11% of its reports
Vomiting after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 1,925 reports · 19% of its reports
Vomiting after Fipronil + S-methoprene (Frontline Plus) 627 reports · 21% of its reports
Vomiting after Flumethrin + Imidacloprid (Seresto) 295 reports · 13% of its reports
Vomiting after Imidacloprid 251 reports · 13% of its reports
Vomiting after Fipronil 417 reports · 30% of its reports
Vomiting after Lufenuron 325 reports · 32% of its reports

All reported side effects of Imidacloprid + Pyriproxyfen in dogs · Medicines most reported with vomiting