Reddening of the skin after Imidacloprid + Moxidectin (Advantage Multi) in dogs

43 reports to the FDA describe reddening of the skin in dogs given Imidacloprid + Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines.

43Reports

44%Marked serious

21%Recovered

2.3%Died or euthanised

2 daysTypical onset

How soon it started

Same day

11 30%

1–2 days

10 27%

3–7 days

1 2.7%

1–4 weeks

8 22%

Over a month

7 19%

How the animals did

Recovered

9 21%

Still unwell when reported

11 26%

Died

1 2.3%

Not known

22 51%

Problems reported at the same time

Itching

26 60%

Didn't stop fleas

15 35%

Hair loss

13 30%

Skin rash or irritation

8 19%

6 14%

6 14%

6 14%

5 12%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause reddening of the skin in dogs?: 43 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 2 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Reddening of the skin with similar medicines

Reddening of the skin after Spinosad (Comfortis) 222 reports · 0.4% of its reports
Reddening of the skin after Lufenuron + Milbemycin Oxime (Sentinel) 51 reports · 0.2% of its reports
Reddening of the skin after Nitenpyram (Capstar) 90 reports · 0.8% of its reports
Reddening of the skin after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) 21 reports · 0.2% of its reports
Reddening of the skin after Fipronil + S-methoprene (Frontline Plus) 26 reports · 0.9% of its reports

All reported side effects of Imidacloprid + Moxidectin in dogs · Medicines most reported with reddening of the skin