Reddening of the skin after Lufenuron + Milbemycin Oxime + Praziquantel (Sentinel Spectrum) in dogs

The FDA has received 21 reports of reddening of the skin in dogs after Lufenuron + Milbemycin Oxime + Praziquantel. That is 0.2% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

21Reports

71%Marked serious

24%Recovered

0.0%Died or euthanised

3 daysTypical onset

How soon it started

Same day

3 25%

1–2 days

3 25%

3–7 days

3 25%

1–4 weeks

1 8.3%

Over a month

2 17%

How the animals did

Recovered

5 24%

Still unwell when reported

13 62%

Not known

3 14%

Problems reported at the same time

8 38%

6 29%

4 19%

4 19%

Skin inflammation

3 14%

Skin sore

3 14%

Abnormal cytology

3 14%

Loss of appetite

3 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Lufenuron stops flea eggs from developing. Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly). Praziquantel treats tapeworms.

Products with this combination include Sentinel Spectrum. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Lufenuron + Milbemycin Oxime + Praziquantel cause reddening of the skin in dogs?: 21 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 3 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Reddening of the skin with similar medicines

Reddening of the skin after Spinosad (Comfortis) 222 reports · 0.4% of its reports
Reddening of the skin after Lufenuron + Milbemycin Oxime (Sentinel) 51 reports · 0.2% of its reports
Reddening of the skin after Imidacloprid + Moxidectin (Advantage Multi) 43 reports · 0.3% of its reports
Reddening of the skin after Nitenpyram (Capstar) 90 reports · 0.8% of its reports
Reddening of the skin after Fipronil + S-methoprene (Frontline Plus) 26 reports · 0.9% of its reports

All reported side effects of Lufenuron + Milbemycin Oxime + Praziquantel in dogs · Medicines most reported with reddening of the skin