Overdose after Ilunocitinib (Zenrelia) in dogs

The FDA has received 22 reports of overdose in dogs after Ilunocitinib. That is 1.0% of all reports for this medicine, compared with 1.3% across reports for all dog medicines.

22Reports

27%Marked serious

18%Recovered

4.5%Died or euthanised

41 daysTypical onset

How soon it started

Same day

4 22%

1–2 days

1 5.6%

3–7 days

0 0.0%

1–4 weeks

4 22%

Over a month

9 50%

How the animals did

Recovered

4 18%

Still unwell when reported

9 41%

Died

1 4.5%

Not known

8 36%

Problems reported at the same time

Didn't work as expected

5 23%

Hair loss

3 14%

Decreased haematocrit

3 14%

Decreased red blood cell count

3 14%

Hair shedding

2 9.1%

Seizures

2 9.1%

Liver problems

2 9.1%

Vomiting

2 9.1%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause overdose in dogs?: 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 41 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Overdose with similar medicines

Overdose after Oclacitinib (Apoquel) 806 reports · 2.8% of its reports
Overdose after Cyclosporine (Atopica) 68 reports · 0.4% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with overdose