Ocular discharge after Ilunocitinib (Zenrelia) in dogs

The FDA has received 24 reports of ocular discharge in dogs after Ilunocitinib. That is 1.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

33%Marked serious

4.2%Recovered

17%Died or euthanised

90 daysTypical onset

How soon it started

Same day

1 5.0%

1–2 days

2 10%

3–7 days

1 5.0%

1–4 weeks

4 20%

Over a month

12 60%

How the animals did

Recovered

1 4.2%

Still unwell when reported

8 33%

Died

1 4.2%

Euthanised

3 13%

Not known

11 46%

Problems reported at the same time

Loss of appetite

7 29%

Skin rash or irritation

5 21%

5 21%

4 17%

4 17%

4 17%

Entropion

4 17%

Death

4 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Ilunocitinib controls itching from allergies (tablet, a JAK inhibitor).

Products with this ingredient include Zenrelia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Ilunocitinib cause ocular discharge in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 90 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Ocular discharge with similar medicines

Ocular discharge after Oclacitinib (Apoquel) 146 reports · 0.5% of its reports
Ocular discharge after Cyclosporine (Atopica) 96 reports · 0.6% of its reports

All reported side effects of Ilunocitinib in dogs · Medicines most reported with ocular discharge