Walking difficulty after Grapiprant (Galliprant) in dogs

The FDA has received 139 reports of walking difficulty in dogs after Grapiprant. That is 1.6% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

139Reports
60%Marked serious
10%Recovered
25%Died or euthanised
23 daysTypical onset
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How soon it started

Same day
16 16%
1–2 days
11 11%
3–7 days
15 15%
1–4 weeks
14 14%
Over a month
47 46%

How the animals did

Recovered
12 8.6%
Recovered with lasting effects
2 1.4%
Still unwell when reported
63 45%
Died
14 10%
Euthanised
21 15%
Not known
27 19%

Problems reported at the same time

Age of the animals

Under 1 year
1
1–3 years
0
4–7 years
9
8–11 years
48
12+ years
79

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause walking difficulty in dogs?
139 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 23 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Walking difficulty with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with walking difficulty