Tarry or black stool after Grapiprant (Galliprant) in dogs

104 reports to the FDA describe tarry or black stool in dogs given Grapiprant. That is 1.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

104Reports
67%Marked serious
29%Recovered
21%Died or euthanised
17 daysTypical onset
SponsoredWorried about your pet? Ask a veterinarian online, 24/7

How soon it started

Same day
9 11%
1–2 days
10 12%
3–7 days
18 22%
1–4 weeks
17 21%
Over a month
28 34%

How the animals did

Recovered
30 29%
Still unwell when reported
32 31%
Died
2 1.9%
Euthanised
20 19%
Not known
20 19%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
4
4–7 years
13
8–11 years
38
12+ years
47

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause tarry or black stool in dogs?
104 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 17 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Tarry or black stool with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with tarry or black stool