Hyperphosphataemia after Grapiprant (Galliprant) in dogs

127 reports to the FDA describe hyperphosphataemia in dogs given Grapiprant. That is 1.4% of all reports for this medicine, compared with 0.6% across reports for all dog medicines, so it is reported unusually often with this medicine.

127Reports
80%Marked serious
3.1%Recovered
39%Died or euthanised
15 daysTypical onset
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How soon it started

Same day
13 13%
1–2 days
11 11%
3–7 days
15 15%
1–4 weeks
22 22%
Over a month
40 40%

How the animals did

Recovered
3 2.4%
Recovered with lasting effects
1 0.8%
Still unwell when reported
44 35%
Died
4 3.1%
Euthanised
46 36%
Not known
29 23%

Problems reported at the same time

Age of the animals

Under 1 year
3
1–3 years
6
4–7 years
6
8–11 years
45
12+ years
65

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause hyperphosphataemia in dogs?
127 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 15 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperphosphataemia with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with hyperphosphataemia