Elevated creatine-kinase (ck) after Grapiprant (Galliprant) in dogs

26 reports to the FDA describe elevated creatine-kinase (ck) in dogs given Grapiprant. That is 0.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports

81%Marked serious

15%Recovered

19%Died or euthanised

31 daysTypical onset

How soon it started

Same day

2 9.5%

1–2 days

1 4.8%

3–7 days

4 19%

1–4 weeks

3 14%

Over a month

11 52%

How the animals did

Recovered

3 12%

Recovered with lasting effects

1 3.8%

Still unwell when reported

11 42%

Died

2 7.7%

Euthanised

3 12%

Not known

6 23%

Problems reported at the same time

15 58%

9 35%

9 35%

7 27%

7 27%

Abnormal ultrasound finding

7 27%

Loss of appetite

6 23%

Hyperkalaemia

5 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause elevated creatine-kinase (ck) in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated creatine-kinase (ck) with similar medicines

Elevated creatine-kinase (ck) after Carprofen (Rimadyl) 242 reports · 0.5% of its reports
Elevated creatine-kinase (ck) after Deracoxib (Deramaxx) 97 reports · 0.9% of its reports
Elevated creatine-kinase (ck) after Meloxicam (Metacam) 27 reports · 0.3% of its reports
Elevated creatine-kinase (ck) after Firocoxib (Previcox) 43 reports · 0.5% of its reports

All reported side effects of Grapiprant in dogs · Medicines most reported with elevated creatine-kinase (ck)