Abnormal ultrasound finding after Grapiprant (Galliprant) in dogs

The FDA has received 213 reports of abnormal ultrasound finding in dogs after Grapiprant. That is 2.4% of all reports for this medicine, compared with 0.5% across reports for all dog medicines, so it is reported unusually often with this medicine.

213Reports
80%Marked serious
8.0%Recovered
31%Died or euthanised
23 daysTypical onset
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How soon it started

Same day
14 9.8%
1–2 days
13 9.1%
3–7 days
16 11%
1–4 weeks
35 24%
Over a month
65 45%

How the animals did

Recovered
16 7.5%
Recovered with lasting effects
1 0.5%
Still unwell when reported
102 48%
Died
14 6.6%
Euthanised
51 24%
Not known
29 14%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
0
4–7 years
10
8–11 years
97
12+ years
104

About this medicine

Grapiprant relieves arthritis pain (a piprant, a newer non-COX NSAID).

Products with this ingredient include Galliprant. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

NSAIDs can affect the stomach, liver and kidneys. Vets usually recommend blood tests before and during long-term use.

Questions owners ask

Can Grapiprant cause abnormal ultrasound finding in dogs?
213 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 23 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Abnormal ultrasound finding with similar medicines

All reported side effects of Grapiprant in dogs · Medicines most reported with abnormal ultrasound finding