Proteinuria after Fluoxetine in dogs

The FDA has received 23 reports of proteinuria in dogs after Fluoxetine. That is 0.9% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports

35%Marked serious

8.7%Recovered

4.3%Died or euthanised

65 daysTypical onset

How soon it started

Same day

0 0.0%

1–2 days

1 6.3%

3–7 days

1 6.3%

1–4 weeks

2 13%

Over a month

12 75%

How the animals did

Recovered

2 8.7%

Still unwell when reported

14 61%

Euthanised

1 4.3%

Not known

6 26%

Problems reported at the same time

Liver problems

10 43%

Loss of appetite

10 43%

Kidney problems

8 35%

Haematuria

7 30%

Lethargy

5 22%

Neutropenia

5 22%

Hypoalbuminaemia

5 22%

Urinary tract infection

5 22%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Fluoxetine treats anxiety and behaviour problems.

Questions owners ask

Can Fluoxetine cause proteinuria in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 65 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Proteinuria with similar medicines

Proteinuria after Gabapentin 201 reports · 2.2% of its reports
Proteinuria after Selegiline (Anipryl) 21 reports · 0.5% of its reports
Proteinuria after Trazodone 42 reports · 1.7% of its reports

All reported side effects of Fluoxetine in dogs · Medicines most reported with proteinuria