Blood problems after Febantel + Praziquantel + Pyrantel (Drontal Plus) in dogs

51 reports to the FDA describe blood problems in dogs given Febantel + Praziquantel + Pyrantel. That is 0.8% of all reports for this medicine, compared with 1.8% across reports for all dog medicines, so it is reported less often than average with this medicine.

51Reports
75%Marked serious
20%Recovered
29%Died or euthanised
7 daysTypical onset
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How soon it started

Same day
7 19%
1–2 days
6 17%
3–7 days
9 25%
1–4 weeks
9 25%
Over a month
5 14%

How the animals did

Recovered
10 20%
Still unwell when reported
7 14%
Died
7 14%
Euthanised
8 16%
Not known
19 37%

Problems reported at the same time

30 59%
15 29%
11 22%
11 22%
10 20%
Decreased packed cell volume (pcv)
8 16%

Age of the animals

Under 1 year
27
1–3 years
2
4–7 years
10
8–11 years
6
12+ years
2

About this medicine

Febantel treats intestinal worms. Praziquantel treats tapeworms. Pyrantel treats roundworms and hookworms.

Products with this combination include Drontal Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Febantel + Praziquantel + Pyrantel cause blood problems in dogs?
51 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 7 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Blood problems with similar medicines

All reported side effects of Febantel + Praziquantel + Pyrantel in dogs · Medicines most reported with blood problems