Neutropenia after Estriol in dogs

31 reports to the FDA describe neutropenia in dogs given Estriol. That is 1.5% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

31Reports
81%Marked serious
6.5%Recovered
42%Died or euthanised
32 daysTypical onset
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How soon it started

Same day
0 0.0%
1–2 days
1 6.7%
3–7 days
3 20%
1–4 weeks
2 13%
Over a month
9 60%

How the animals did

Recovered
1 3.2%
Recovered with lasting effects
1 3.2%
Still unwell when reported
11 35%
Died
3 9.7%
Euthanised
10 32%
Not known
5 16%

Problems reported at the same time

Age of the animals

Under 1 year
0
1–3 years
3
4–7 years
1
8–11 years
20
12+ years
7

About this medicine

Type: medicine.

Questions owners ask

Can Estriol cause neutropenia in dogs?
31 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 32 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neutropenia with similar medicines

All reported side effects of Estriol in dogs · Medicines most reported with neutropenia