Leucopenia after Estriol in dogs

34 reports to the FDA describe leucopenia in dogs given Estriol. That is 1.7% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

34Reports
82%Marked serious
2.9%Recovered
50%Died or euthanised
26 daysTypical onset
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How soon it started

Same day
2 12%
1–2 days
1 5.9%
3–7 days
2 12%
1–4 weeks
5 29%
Over a month
7 41%

How the animals did

Recovered
1 2.9%
Still unwell when reported
9 26%
Died
4 12%
Euthanised
13 38%
Not known
7 21%

Problems reported at the same time

19 56%
15 44%
Decreased packed cell volume (pcv)
8 24%

Age of the animals

Under 1 year
0
1–3 years
1
4–7 years
3
8–11 years
16
12+ years
13

About this medicine

Type: medicine.

Questions owners ask

Can Estriol cause leucopenia in dogs?
34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 26 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Leucopenia with similar medicines

All reported side effects of Estriol in dogs · Medicines most reported with leucopenia