Swollen vulva after Estriol in dogs

The FDA has received 342 reports of swollen vulva in dogs after Estriol. That is 17% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

342Reports

85%Marked serious

9.9%Recovered

7.6%Died or euthanised

16 daysTypical onset

How soon it started

Same day

17 6.9%

1–2 days

11 4.4%

3–7 days

29 12%

1–4 weeks

117 47%

Over a month

74 30%

How the animals did

Recovered

31 9.1%

Recovered with lasting effects

3 0.9%

Still unwell when reported

233 68%

Died

2 0.6%

Euthanised

24 7.0%

Not known

49 14%

Problems reported at the same time

Genital tract licking

57 17%

Vaginal discharge

51 15%

Loss of appetite

42 12%

Didn't work as expected

31 9.1%

27 7.9%

26 7.6%

20 5.8%

19 5.6%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

159

About this medicine

Type: medicine.

Questions owners ask

Can Estriol cause swollen vulva in dogs?: 342 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 16 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Estriol in dogs · Medicines most reported with swollen vulva