Vaginal haemorrhage after Estriol in dogs

67 reports to the FDA describe vaginal haemorrhage in dogs given Estriol. That is 3.3% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

67Reports

73%Marked serious

24%Recovered

12%Died or euthanised

13 daysTypical onset

How soon it started

Same day

1 2.4%

1–2 days

1 2.4%

3–7 days

13 31%

1–4 weeks

18 43%

Over a month

9 21%

How the animals did

Recovered

15 22%

Recovered with lasting effects

1 1.5%

Still unwell when reported

33 49%

Died

3 4.5%

Euthanised

5 7.5%

Not known

10 15%

Problems reported at the same time

27 40%

15 22%

9 13%

8 12%

6 9.0%

6 9.0%

Didn't work as expected

5 7.5%

Vomiting

4 6.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Estriol cause vaginal haemorrhage in dogs?: 67 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 13 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Estriol in dogs · Medicines most reported with vaginal haemorrhage