Vaginal discharge after Estriol in dogs

The FDA has received 80 reports of vaginal discharge in dogs after Estriol. That is 4.0% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

80Reports

89%Marked serious

23%Recovered

6.3%Died or euthanised

10 daysTypical onset

How soon it started

Same day

6 12%

1–2 days

5 9.8%

3–7 days

7 14%

1–4 weeks

21 41%

Over a month

12 24%

How the animals did

Recovered

16 20%

Recovered with lasting effects

2 2.5%

Still unwell when reported

48 60%

Died

2 2.5%

Euthanised

3 3.8%

Not known

9 11%

Problems reported at the same time

Swollen vulva

51 64%

Loss of appetite

16 20%

Vaginal haemorrhage

15 19%

Genital tract licking

15 19%

Didn't work as expected

10 13%

Attractiveness to males

8 10%

Lethargy

6 7.5%

Weight loss

6 7.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Estriol cause vaginal discharge in dogs?: 80 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 10 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Estriol in dogs · Medicines most reported with vaginal discharge